The .458 Lott is a .458 caliber belted hunting cartridge designed as a replacement for the less powerful .458 Winchester Magnum. It is based on the full length .375 H&H Magnum blown out and shortened to 2.800 inches (71.1 mm). The cartridge is designed for the purpose of hunting African dangerous game.

The .458 Lott was designed in response to perceived inadequacies and problems encountered with the .458 Winchester Magnum. The cartridge provides a distinct step up in performance over the .458 Winchester Magnum.